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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: The COX-2-derived PGE2 autocrine contributes to bradykinin-induced matrix metalloproteinase-9 expression and astrocytic migration via STAT3 signaling

Fig. 2

BK induces MMP-9 expression via EP receptors in RBA cells. Cells were pretreated with or without Sc-19220 (Sc, 3 μM), L798-106 (L798, 3 μM), or GW627368 (GW, 1 μM) for 1 h, and then treated with BK (10 nM) for the indicated times. The conditioned media were collected and analyzed by gelatin zymography described under Methods. Data are expressed as mean ± SEM of three independent experiments (N = 3). *P < 0.05, as compared with the respective values of cells stimulated with BK only (control) at the same time. The image represents one of three similar experiments

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Cell Communication and Signaling

ISSN: 1478-811X