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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Correction to: Metabolic syndrome increases senescence-associated micro-RNAs in extracellular vesicles derived from swine and human mesenchymal stem/stromal cells

Fig. 3

Effects of MSC-derived EVs in PK1 cells and pig kidney. a Co-cultured with MetS MSC-EVs, PK1 cells showed higher senescence.*p < 0.05 vs PK1, †p < 0.05 vs PK1 + Lean-EVs. b PKH-26-labeled EVs (red) were detected in PK1 cells. c Representative kidney staining with immunofluorescent SA-b-Gal (left top) and trichrome (left bottom), and respective quantification. Lean EVs attenuated cellular senescence and fibrosis in vivo in injured kidneys, whereas MetS EVs failed to blunt them. d Pkh-26-labeled EVs (red) were detected in frozen section in the RVD kidney. *p < 0.05 versus Lean, †p < 0.05 vsersu RVD, ‡p< 0.05 versus RVD + Lean-EVs

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Cell Communication and Signaling

ISSN: 1478-811X