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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Tyrosine 192 within the SH2 domain of the Src-protein tyrosine kinase p56Lck regulates T-cell activation independently of Lck/CD45 interactions

Fig. 2

Block of T-cell development in knock-in mice expressing the phosphomimetic LckY192E mutant. a Total numbers of thymocytes obtained from Lckwt and LckY192E knock-in mice. b Thymic subpopulations were identified upon staining with CD4 and CD8 antibodies by flow cytometry. c Percentages of the thymocyte subpopulations of several experiments are shown. d Numbers of total peripheral T cells and of peripheral CD4+ and CD8+ T cell subsets. Each dot represents one mouse. Mean values of all characterized mice + SEM are represented. Statistical analyses were performed using an unpaired Student’s t test, ****p < 0.0001; ***p < 0.001

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