TY - JOUR AU - Kästle, Matthias AU - Merten, Camilla AU - Hartig, Roland AU - Kaehne, Thilo AU - Liaunardy-Jopeace, Ardiyanto AU - Woessner, Nadine M. AU - Schamel, Wolfgang W. AU - James, John AU - Minguet, Susana AU - Simeoni, Luca AU - Schraven, Burkhart PY - 2020 DA - 2020/11/23 TI - Tyrosine 192 within the SH2 domain of the Src-protein tyrosine kinase p56Lck regulates T-cell activation independently of Lck/CD45 interactions JO - Cell Communication and Signaling SP - 183 VL - 18 IS - 1 AB - Upon engagement of the T-cell receptor (TCR), the Src-family protein tyrosine kinase p56Lck phosphorylates components of the TCR (e.g. the TCRζ chains), thereby initiating T-cell activation. The enzymatic activity of Lck is primarily regulated via reversible and dynamic phosphorylation of two tyrosine residues, Y394 and Y505. Lck possesses an additional highly conserved tyrosine Y192, located within the SH2 domain, whose role in T-cell activation is not fully understood. SN - 1478-811X UR - https://doi.org/10.1186/s12964-020-00673-z DO - 10.1186/s12964-020-00673-z ID - Kästle2020 ER -