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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Synergistic effects of EMPs and PMPs on pulmonary vascular leakage and lung injury after ischemia/reperfusion

Fig. 5

The beneficial effect of blebbistatin and amitriptyline on vascular leakage and lung injury after I/R in rats. a Beneficial effect of EMP inhibitor BLE (blebbistatin) and PMP inhibitor AMI (amitriptyline) on pulmonary vascular permeability reflected by leakage of Evan Blue. b Effect of BLE and AMI alone, and their combined use on pulmonary vascular permeability reflected by leakage of FITC-labeled albumin. c, d Beneficial effect of BLE (10 mg/kg) and AMI (5 mg/kg)on pulmonary inflammation of I/R rats. The numbers of inflammatory cells were determined in 10 randomly selected nonoverlapping fields at 400 × magnification in respective sections of the individual rat lung. e Beneficial effect of BLE and AMI on BALF proteins after I/R. f Schematic diagram of the mechanism by which EMPs mediate pulmonary sequestration of platelets and PMP production and EMPs and PMPs regulate pulmonary vascular permeability. The data are the mean ± SD of n experiments (n = 8). **P < 0.01 versus the sham group; ##P < 0.01 versus the I/R group; @P < 0.05, @@P < 0.01 versus the BLE group; &&P < 0.01 versus the AMI group

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