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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Synergistic effects of EMPs and PMPs on pulmonary vascular leakage and lung injury after ischemia/reperfusion

Fig. 4

The mechanism of miR-155 and miR-126 in H/R-EMP and H/R-PMP induced vascular leakage. a, b Effect of H/R-EMPs on the expression of vascular permeability-related proteins in pulmonary vasculature of rats. c Effect of H/R-EMPs on vascular permeability-related proteins in microvasculature of rats (scale bars 25 μm). d, e Effect of H/R-PMPs on the expression of vascular permeability-related proteins in pulmonary vasculature of rats. f, g Effect of miR-155 high and low containing EMPs on the expression of vascular permeability-related proteins in VECs. h, i Effect of miR-126 high and low containing PMPs on the expression of vascular permeability-related proteins in VECs. j, k Effect of miR-155 on the transcription of ZO-1 and claudin-5 as measured by a dual-luciferase reporter system. Data are mean ± SD of n experiments (n = 8). Veh Ctl vehicle control, WT wild type; Mut mutant type. *P < 0.05 miR-155 over versus miR-Ctl in ZO-1 and Cldn-5 WT group; **P < 0.01 versus normal group; #P < 0.05 ZO-1 WT group versus ZO-1 Mut group with miR-155 over, or cldn-5 WT group versus cldn-5–1 Mut group with miR-155 over

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