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Table 2 Modulation of microRNA by probiotics in pathological conditions

From: Effects of therapeutic probiotics on modulation of microRNAs

MicroRNA Probiotics Probiotic concentrations Expression Target gene Effects Model Sample (n) Ref
miR-215-5p, miR-10b-5p, miR-21-5p, miR-26a-5p, miR-22-3p, miR-10a-5p, miR-148a-3p, miR-194,
miR-92-3p, miR-30d,
miR-181a-5p,
miR-429-3p,
let-7f-5p,
miR-30a-5p, miR-133a-3p, miR-199-3p, miR-30c-5p, miR-200a-3p, miR-126-5p, miR-27b-3p
Lactobacillus plantarum Z01 (LPZ01) 1 × 108 CFU/mL Down-regulation of miR-215-5p, miR-3525, miR-122-5p and up regulation of miR-193a-5p, miR-375 and miR-215-5p cAMP-dependent protein kinase activity, stress-activated MAPK cascade, MAPK and Wnt signaling pathways. Decrease inflammation in S. typhimurium infection in neonatal broiler chicks In vivo
(Newly hatched chicks)
- [172]
miR-135b, miR-155
miR-26b and miR-18a
Lactobacillus acidophilus and Bifidobacterium bifidum (Bla/016P/M) 1 × 109 CFU/g and 1 × 109 CFU/g Up regulation of miR-135b, miR-155 and down regulation of miR-26b, miR-18a APC, PTEN, KRAS, and PU.1 -. In vivo (Mice) - [173]
miR-423-5p Enterococcus faecium NCIMB 10415 3.6 × 106 CFU/g Up regulation of miR-423-5p Immunoglobulin lambda light C region (IGLC) and immunoglobulin kappa constant (IGKC) - In vivo (Landrace pigs) - [174]
Lactobacillus rhamnosus GG, Bifidobacterium animalis subsp. lactis Bb-12 and L.
acidophilus La-5
5 × 1010 CFU, 5 × 1010 CFU and 5 × 109 CFU     Human 54 [175]
miR-122a Lactobacillus rhamnosus GG 1 × 109 CFU Down-regulation of miR-122a ? Decrease ethanol-elevated miR122a levels and attenuate ethanol-induced liver injury In vivo
(Mice)
- [176]
miR-146a Escherichia coli Nissle 1917 (EcN) (O6:K5:H1) NA Up-regulation of miR-146a in both EPEC and ECN IRAK1 and TRAF6 Reduce IL-8 as well as CXCL1 in T84 cells In vitro
(Human epithelial and THP-1 cells)
- [177]
miR-21,
miR-92a,
miR-155,
miR-663
Lactobacillus
acidophilus (La) ATCC strain 4356
109 – 1010 CFU/ml Up-regulation of miR-21 and down-regulation of
miR-155
MiR-92a targets
integrin a5, klf-2 and klf-4/ MiR-155 targets AtR1 and Ets-1/ MiR-663 targets VEGF
Reduce apoptosis, necrosis and inflammatory In vitro(HUVEC) - [178]
miR-155,
miR-223,
miR-150,
miR-375 and miR-143
Lactobacillus fermentum CECT5716 and L. salivarius CECT5713 5 × 108 CFU Down-regulation of miR-155, miR-223 and miR-150 and up-regulation of miR-143 c-Myb (miR-150) Reduce expression of pro-inflammatory cytokine IL-1β In vivo (Mice) - [179]
miR-203,
miR-483-3p and miR-595
Escherichia coli Nissle 1917 (EcN) NA Up-regulation of miR-483-3p and down-regulation of miR-203 and miR-595 miR-203 targets tight junction protein ZO-2/
miR-595 targets Mucin-4-precursor/ miR-483-3p targets beta-defensin 111 precursor
Improve effects of EcN. In vitro (T84 epithelial cells) - [180]
miR-21 and miR-200b Leuconostoc mesenteroides NA Down-regulation of miRNA-21 and miRNA-200b NF-kB inhibitory subunit (IKB) and RelA Induce apoptosis in colon cancer cell line by up-regulation of MAPK1, Bax, and caspase 3, and down-regulation of AKT, NF-kB, Bcl-XL In vitro
(HT-29 cells)
- [181]
miRNA-29a
miRNA-29b
miRNA-29c
A mixture of: Lactobacillus plantarum DSM 24730, Streptococcus thermophiles
DSM 24731, Bifidobacterium breve DSM 24732, L. paracasei DSM 24733, L. delbrueckii subsp. Bulgaricus DSM
24734, L. acidophilus DSM 24735, B. longum DSM 24736, and B. infantis DSM 24737
1.8 × 109 CFU Unchanged - -. Human 10 [182]
miR-146a and miR-155 Lactobacillus rhamnosus GG (LGG) and L.
delbrueckii subsp. Bulgaricus (L.del)
NA Up-regulation of miR-155 and down regulation of miR-146a. - Down-regulation of p38 while IκB expression was significantly decreased in L. del-treated DCs. In vitro
(Human monocyte-derived dendritic cells)
- [183]
miR-143,
miR-150,
miR-155,
miR-223, and miR-375
Escherichia coli
Nissle 1917 (EcN)
5 × 108 CFU miR-150, miR-155, and miR-223 were up-regulated. miR-375 was down-regulated. Housekeeping gene (SNORD95) The intestinal anti-inflammatory effects of EcN were associated with altered gut microbiome in mouse experimental colitis. In vivo (Mice) - [184]
miR-148a Bifidobacterium bifidum MIMBb75 B. bifidum NCC390 or B. longum NCC2705 1 × 108 CFU Up-regulation after 1 and 4 hours, but not after 24 h (in vitro)
Up-regulation after 2 but not 14 days (in vivo)
EPAS1 Reduce EPAS1 expression in Caco-2 cells and mouse cecum. In vitro (Caco-2 cells) and In vivo (Mice) - [185]
miR-744 Lactobacillus crispatus 2743 and L. gasseri 3396 5 × 107 CFU/ml Up-regulation ARHGAP5 Trigger lactic acid-induced migration and invasion in SiHa cells. In vitro (SiHa cells) - [186]
Let-7b Encapsulated mixture of Lactobacillus plantarum, L. acidophilus -11 and Bifidobacterium longum-88 or encapsulated mixture of Enterococcus faecium and Bacillus subtilis 2.6×1014 CFU in first mixture and 5.0×108 CFU in second mixture Down-regulation HMGA2
FIGN
MAPK6
ARID3B
- Human and In vitro (NCM460 cells) 79 [187]