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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: Lactic acid promotes metastatic niche formation in bone metastasis of colorectal cancer

Fig. 8

Inhibiting PI3K pathway attenuates the bone metastasis from CRC. a RT-PCR analysis detected the expression of fibrotic markers in CD115(+) precursors after treated by PI3K antagonist. b Representative images of expression of Collagen 5 in tibial cancellous bone in LA treated group with/without PI3K antagonist at 10 days post injection of MC-38 cells (Scale bar = 50 μm). c Quantification of area of Collagen 5 in (b). d Safranin O and fast green staining and trap staining analyzed the trabecular area and the TRAP(+) area in bone surface at 3 weeks after injection of MC-38 cells in LA as well as PI3K antagonist treated group vs. LA treated group (Scale bar = 50 μm). e The quantification of percentage of trabecula area and (f) the number of osteoclasts in (d). g Survival analysis in LA combined with PI3K antagonist treated group vs. LA-treated group in bone metastasis model of CRC. *p < 0.05, **p < 0.01, ***p < 0.001

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