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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Lysophosphatidic acid-RAGE axis promotes lung and mammary oncogenesis via protein kinase B and regulating tumor microenvironment

Fig. 6

Metastasis and immune cells infiltration in a xenograft model of mammary cancer cells. a Representative images show metastasis (Yellow arrows) of MDA MB-231 cells in peritoneal cavity of nude mice injected with control and RAGE shRNA treated MDA MB-231 cells after exogenous LPA treatments. Representative images of (b) liver, (c) lungs with heart and (d) kidneys of nude mice show metastasis of control shRNA treated MDA MB-231 upon LPA induction. e, f Representative images show markers for macrophage (F4/80), angiogenesis (CD34) and leukocyte (CD45) infiltration in control shRNA and RAGE shRNA MDA MB-231 and MCF-7 tumors and quantification of % area DAB in sections of mice treated with LPA and their quantifications. g Schematic representation of LPA via RAGE promotes lung and mammary carcinogenesis and epithelial to mesenchymal transition trough the PKB pathway. For all experiments, data are means ± SD., n = 3–7. ***P ≤ 0.001

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