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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Lysophosphatidic acid-RAGE axis promotes lung and mammary oncogenesis via protein kinase B and regulating tumor microenvironment

Fig. 2

LPA induces in vivo tumorigenicity of lung cancer cells via RAGE. a Levels of RAGE in control shRNA and RAGE shRNA treated A549 cells. b Left, Representative images showing tumor foci on peritoneal wall of nude mice injected with control shRNA and RAGE treated A549 cells with and without LPA stimulation. Right, Quantification of number of tumor foci on peritoneal wall of nude mice injected with control shRNA and RAGE treated A549 cells with and without LPA stimulation (n = 4 for each group). c Representative H & E images of tumor section from peritoneal wall of nude mice injected with control shRNA and RAGE treated A549 cells stimulated with or without LPA stimulation. d Representative images show Ki67 immunohistochemical staining of the tumor sections of nude mice injected with control shRNA and RAGE treated A549 cells with and without LPA stimulation and its quantitative representation. e, f Representative images show markers for macrophage (F4/80), angiogenesis (CD34) and leukocyte (CD45) infiltration in control shRNA and RAGE shRNA A549 tumors and quantification of % area DAB in sections of mice treated with LPA and their quantifications. For all experiments, data are means ± SD., ***P ≤ 0.001

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Cell Communication and Signaling

ISSN: 1478-811X