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Fig. 10 | Cell Communication and Signaling

Fig. 10

From: The ferroptosis and iron-metabolism signature robustly predicts clinical diagnosis, prognosis and immune microenvironment for hepatocellular carcinoma

Fig. 10

Erastin treatment suppressed proliferation of HCC in vitro. a The chemical formula of erastin. b-c The CCK-8 assay showed that erastin inhibited the proliferation of SK-HEP1 cells (a) and SMMC-7721 cells (b) in a dose-dependent manner. d-g Erastin stimulation enhanced ROS accumulation in SK-HEP1 cells (d and f) and SMMC-7721 cells (e and g). h-i Erastin treatment increased iron levels in SK-HEP1 cells (h) and SMMC-7721 cells (i). j-k Erastin inhibited the survival and proliferation of SK-HEP1 cells (j) and SMMC-7721 cells (k) by inducing ferroptosis

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