Skip to main content
Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Receptor-interacting protein kinase 1 is a key mediator in TLR3 ligand and Smac mimetic-induced cell death and suppresses TLR3 ligand-promoted invasion in cholangiocarcinoma

Fig. 5

RIPK1 expression in primary CCA tissues and the expression status of RIPK1 and TLR3 on the survival of patients.a The representative cytoplasmic RIPK1 immunostaining in tumor area and adjacent normal tissues. Black arrowheads indicate bile ducts. b The median of H-score of RIPK1 staining in tumor area, adjacent normal tissues and cholangiocytes, liver cells in normal liver tissues. The difference between the median of H-score of tumor and adjacent tissues was calculated by one-way ANOVA and presented asp-value. c Distribution of RIPK1 expression according to H-score of tumor area and adjacent area. RIPK1 and TLR3 expression were classified into four groups according to low and high expression. Kaplan-Meier disease free survival curves stratified by (d) four groups of TLR3 and RIPK1 expression (Low Low, High High, Low High, High Low) and (e) two groups of TLR3 and RIPK1 expression (High High, Low Low)

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X