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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: JARID1B promotes colorectal cancer proliferation and Wnt/β-catenin signaling via decreasing CDX2 level

Fig. 4

JARID1B inhibited CDX2 expression in CRC cells. a The microarray profiling of gene expression in DLD-1-shJARID1B cells. b, c qRT-PCR and western blot detected CDX2, β-catenin, c-MYC, cyclinD1 expression in DLD-1 cells transfected with shNC or shJARID1B. d, e qRT-PCR and western blot detected CDX2 expression in LOVO cells transfected with vector or Flag-JARID1B. f, h Western blot analysis and qRT-PCR of CDX2 protein levels in CRC tissues and in paired adjacent tissues. g, i Scatter plots showed a negative correlation between JARID1B and CDX2 at the mRNA and protein levels in fresh 54 CRC samples. j Kaplan-Meier analysis for 130 CRC patients follow-up data showed that the prognosis was the poorest for patients with both high JARID1B expression and low CDX2 expression. *p < 0.05, **p < 0.01

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Cell Communication and Signaling

ISSN: 1478-811X