Fig. 3
From: The role of mitophagy in innate immune responses triggered by mitochondrial stress
Functions of mitophagy in innate immune responses triggered by mitochondrial stress. Mitochondrial stress triggers the release of mtDNA, mtROS, ATP and cytochrome c into the cytosol and the externalization of cardiolipin, which lead to IL-1β secretion, type I IFN response and apoptosis. In addition, mitochondrial stress causes the dissipation of the mitochondrial membrane potential, which subsequently initiates the mitophagy process. Mitophagy attenuates the secretion of IL-1β, type I IFN responses and apoptosis by degrading dysfunctional mitochondria. In turn, activated caspase-1 can inhibit mitophagy by cleaving Parkin