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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: H. pylori modulates DC functions via T4SS/TNFα/p38-dependent SOCS3 expression

Fig. 1

H. pylori infection elicits cytokine and chemokine secretion as well as SOCS expression in moDCs. DCs were re-plated in fresh medium,H. pylori strain P12 was harvested in PBS and added to the cells at MOI = 5. a Heatmap depicting cytokine and chemokine secretion by DCs infected for the indicated times, ranging from 1 to 48 h, analyzed by Multiplex Assay. b Detailed presentation of secretion of IL-6, IL-8, IL-12 and TNFα by infected moDCs in a time-dependent manner. Each dot represents an individual donor; the horizontal line in each column indicates the mean value of one experiment comprising 4 donors. (N = 4) cSOCS1, SOCS2, SOCS3 mRNA expression was monitored by qRT-PCR. Bars represent mean + SD of three experiments comprising six individual donors. (N = 6) For statistical analysis, one-way ANOVA with a Sidak post-hoc test was performed. *p < 0.05, **p < 0.01, ***p < 0.001

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