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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: LncRNAH19 improves insulin resistance in skeletal muscle by regulating heterogeneous nuclear ribonucleoprotein A1

Fig. 6

The effects of H19-hnRNPA1 complexes in metabolism. (a) Representative tracings of OCR measured in the hnRNPA1 overexpression and control muscle cells in the presence of H19 knockdown. Basal mitochondrial respiration (b), maximal mitochondrial respiration (c), ATP production (d) and proton leak (e) of OE-hnRNPA1 and OE-vector transfected muscle cells in the presence of H19 knockdown. (f) The protein levels of PGC1a and CPT1b of OE-hnRNPA1 and Vector transfected muscle cells in the presence of H19 knockdown. (g) Proposed model of H19-mediated regulation of lipid contents in skeletal muscle. Quantification was based on 3 independent transfection/infection experiments. Numbers were the mean ± SD. ***p < 0.001, *p < 0.05, n.s, not significant

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Cell Communication and Signaling

ISSN: 1478-811X