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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: LncRNAH19 improves insulin resistance in skeletal muscle by regulating heterogeneous nuclear ribonucleoprotein A1

Fig. 1

H19 overexpression in db/db mice ameliorates glucose intolerance and lipid ectopic accumulation. (a) The expression level of H19 was decreased in skeletal muscle of db/db mice. (b) Ad-H19 injection resulted in H19 overexpression in skeletal muscle of db/db mice. Fasting glucose levels (c) and serum GA levels (d) in db/db mice after H19 overexpression. (e) Left: OGTTs at 2 weeks after viral injection. Right: area under the curve (AUC) data. (f) Fasting serum insulin levels of db/db mice after H19 overexpression. Serum TG (g) and Skeletal muscle TG (h) levels in db/db mice after H19 overexpression. Representative images of Oil Red O staining assays (i) and H&E staining assays (j) of db/db mouse skeletal muscle after H19 overexpression. n = 6 mice per genotype. Numbers were the mean ± SD. *p < 0.05, **p < 0.01, n.s, not significant

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