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Table 3 Dissociation constant (Kd) values of C212 with different Hsp90 domains

From: Curcumin derivative C212 inhibits Hsp90 and eliminates both growing and quiescent leukemia cells in deep dormancy

Compound

Fmax

Kd (μM)

R2

N-Hsp90

80.8 ± 1.1

36.3 ± 1.0

0.999

M-Hsp90

195.8 ± 2.5

38.7 ± 0.9

0.999

C-Hsp90

32.8 ± 0.9

15.3 ± 1.2

0.995

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Cell Communication and Signaling

ISSN: 1478-811X