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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Curcumin derivative C212 inhibits Hsp90 and eliminates both growing and quiescent leukemia cells in deep dormancy

Fig. 5

C212 drives leukemia cells into deep quiescence. (a and b) Leukemia cells were serum-starved for the indicated durations (before t0) to induce quiescence/slow-growth as in Fig. 4 a and b; cells were then either kept in starvation condition (indicated by a black line), or stimulated with 2.5% serum (indicated by a red line) for 43 h in HL60 cells (a) or 24 h in K562 cells (b), followed by cell harvesting and Click-iT EdU assay. C212 at indicated doses was included in the last segment of starvation and though serum stimulation, as indicated with a red dash line. EdU (2 μM) was added between t0 and harvesting. c and d Same asa and b, except that C212 was included only in the last segment of starvation (as indicated with a red dash line).e and f Same as a andb, except that C212 was included only during serum stimulation (as indicated with a red dash line). Error bar, SEM (n = 2); * p < 0.05, ** p < 0.01, *** p < 0.001 (over control at 0 μM)

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