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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Alpha-1 antitrypsin deficient individuals have circulating extracellular vesicles with profibrogenic cargo

Fig. 7

Plasma derived EV mediated liver fibrosis in AATD individuals. EVs are small vesicular structures that are shed by different cells and provide various autocrine and paracrine signaling cues. AATD mediated immune complications, such as lung disease, panniculitis, cardiovascular risks, and mesangial-capillary glomerulonephritis suggest a contribution from a variety of activated immune cells as well as parenchymal cells. EVs released by activated immune cells and injured parenchymal cells carry a pro-fibrotic cargo with the ability to promote liver fibrosis through activation of HSCs. AATD plasma derived EVs induced HSC trans differentiation and activation leading to deposition of ECM and fibrotic phenotype

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Cell Communication and Signaling

ISSN: 1478-811X