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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Alpha-1 antitrypsin deficient individuals have circulating extracellular vesicles with profibrogenic cargo

Fig. 3

Differential miRNA Expression Profiles among plasma derived EV miRNAs from healthy and AATD individuals with liver disease. a Volcano plot of total and b differentially expressed miRNAs in ZZ individuals compared with MM healthy controls. Plotted along the x-axis is the mean of log2 fold-change and the y-axis is the negative logarithm of the -log P-values. Red points represent significantly upregulated miRNAs and blue points represent significantly downregulated miRNAs. c Relative expression of selected miRNAs in the plasma exosomal fraction from MM and ZZ subjects using q-PCR. d Bar graph indicating the number of miRNAs that are predicted to target genes in each category listed on the x-axis. d and e Molecular networks linking highly differentially expressed microRNAs (miRNAs) and their target genes involved in hepatic stellate cell activation between AATD individuals and healthy controls. Upregulated miRNAs are in red and downregulated miRNAs are green

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