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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Alpha-1 antitrypsin deficient individuals have circulating extracellular vesicles with profibrogenic cargo

Fig. 2

Comparison of EV-associated and plasma cytokines and chemokines between control and AATD subjects. a Representative liver biopsies show increasing PAS + D globule grade, indicating ZAAT accumulation. Black arrows highlight cells with PAS-D globules. Scale bar represents 100 μ m. b The distribution of CRP levels in MM and ZZ individuals. c The levels of total and polymeric AAT in plasma derived EVs pooled from 4 MM and 4 ZZ individuals. Calnexin (CNX) has been loaded as negative marker for EVs. d The levels of differential expressed free and EV-associated cytokines in plasma samples from MM individuals, compared to ZZ individuals, n = 20, *p = 0.0101, **p = 0.0015, ***p = 0.0003

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Cell Communication and Signaling

ISSN: 1478-811X