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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Icariside I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity

Fig. 4

Icariside I promotes ATP or nigericin-induced ASC oligomerization but has no effect on K+ efflux. a Western blot analysis of ASC oligomerization in cell lysates of LPS-primed BMDMs treated with various doses of Icariside I and then stimulated with ATP. b, c Western blot analysis of ASC oligomerization in cell lysates of LPS-primed BMDMs treated with Icariside I (20 μM) and then stimulated with ATP, nigericin, poly(I:C), SiO2, poly (dA:dT), Salmonella or Pam3CSK4-primed BMDMs treated with Icariside I (20 μM) and then stimulated with LPS.  Data are represented from at least three biological samples. d Qualification of potassium efflux in LPS-primed BMDMs treated with Icariside I (20 μM) and then stimulated with ATP and nigericin. Data are represented as the mean ± SD from at least three biological samples. NS, not significant

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Cell Communication and Signaling

ISSN: 1478-811X