Fig. 3
From: Non-canonical Fzd7 signaling contributes to breast cancer mesenchymal-like stemness involving Col6a1
Fzd7 knockdown suppresses BC tumorigenesis and metastasis. a Growth curves of xenograft tumors derived from MDA-MB-231 cells transfected with shCtrl or shFZD7 were shown (8 mice in each group). b Tumors were harvested and weighed 10 weeks post-inoculation. c Latent periods of xenograft tumors were compared between two groups. d Expression of Ki67 and cleaved caspase-3 (Cl-caspase3) in xenograft tumors was determined by Immunohistochemistry. Ki67-positive cells and cleaved caspase-3 -positive cells were quantified. e Macro-metastasis on mouse lung surface was shown. The numbers of lung macro-metastasis were counted. f Lung metastasis was shown by HE staining. Data are expressed as Mean ± s.e.m