Fig. 5

Enhanced hepatic VLDLR and CD36 levels in Sirt3-deficient mice fed a HFD. mRNA abundance (a) and protein levels (b) of VLDLR in livers of WT and Sirt3^−/− mice fed either a standard chow or a HFD. CD36 (c), total and phospho-Nrf2 (d), Keap1 (e) and NQO1 (f) protein levels. g, ROS levels. h, PPARγ protein levels. Data are presented as the mean ± S.D. (n = 6 per group). a, p < 0.05 vs. WT mice fed a standard chow. b, p < 0.05 vs. WT mice fed a HFD. c, p < 0.05 vs. Sirt3^−/− mice fed a standard chow