Fig. 4

Lipogenesis is not increased in Sirt3-deficient mice fed a HFD. a, protein levels of total and phospho-mTOR in liver from wild-type (WT) and Sirt3^−/− mice fed either a standard chow or a HFD. b, protein levels of precursor (p) and mature (m) forms of SREBP1. c, hepatic Scd1 and Fas mRNA levels. Data are presented as the mean ± S.D. (n = 6 per group). a, p < 0.05 vs. WT mice fed a standard chow. b, p < 0.05 vs. WT mice fed a HFD. c, p < 0.05 vs. Sirt3^−/− mice fed a standard chow