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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Repositioning liothyronine for cancer immunotherapy by blocking the interaction of immune checkpoint TIGIT/PVR

Fig. 1

The expression level of PVR in tumor tissues and cell lines. a Human PVR expression levels in different tumor types from TCGA database were determined by TIMER (*P < 0.05, **P < 0.01, ***P < 0.001). b Increased or decreased PVR expression in datasets of different cancers compared with normal tissues in the Oncomine database. (Threshold: P < 0.001, fold change> 2, gene ranking of top 10%). c PVR expression level in colorectal cancers, polyps and normal tissues from GEO cohorts. Statistical analysis was conducted with unpaired Student’s t-test for datasets GSE37182 and GSE41258, and conducted with paired Student’s t-test for dataset GSE10972. ***, P < 0.001. d Flow cytometry analysis of PVR expression on human and murine colorectal cell lines. The red-shaded histogram represents anti-human PVR PE (left). The red-shaded histogram represents anti-mouse PVR APC (right). The gray-shaded histogram represents the matched isotype control. Representative histogram of three independent experiments were shown

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