Table 1 Signaling processes that calcineurin plays roles in and example substrates

Transcription

NFATs (nuclear factors of activated T-cells) [3, 4, 8,9,10,11,12,13,14,15,16]

FOXO (forkhead transcription factors) [17, 18]

MEF2 (myocyte-specific enhancer factor 2) [13, 15, 16]

TFEB (transcription factor EB) [12, 16, 18, 19]

Receptors and channels

AMPARs (α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptors) [20, 21]

NMDARs (NMDA-type ionotropic glutamate receptors) [20, 21]

TRESK (tandem-pore-domain weakly inward rectifying potassium channels (TWIK)-related spinal cord potassium channels) [22,23,24]

NHE1 (Na+/H+ exchanger 1) [16, 25, 26]

Mitochondria

DRP1 (dynamin-related protein 1) [27]

BAD (Bcl-2/Bcl-XL-antagonist, causing cell death) [28,29,30]

Microtubules

tau [31]

MAP2 [31]