Fig. 3
PAI-1 expression in HCC tissues associates with poor clinical outcome and YAP target gene expression. a Table summarizing the results of patient sample analysis. Positive: high level expression positively associates with poor clinical outcome; negative: high level expression negatively associates with poor clinical outcome. Transcriptome data were derived from 242 HCC patients. ns - no significant difference, *p ≤ 0.05, ***p ≤ 0.001. Statistical test: log-rank test. b Overall survival and cancer recurrence of HCC patients with high or low PAI-1 transcript levels are shown by Kaplan-Meier curves. *p ≤ 0.05, ***p ≤ 0.001. Statistical test: log-rank test. c Pie chart illustrating ≥2-fold PAI-1 overexpression at the mRNA level in HCC patient samples compared to corresponding normal tissue (real-time PCR). In the lower part, exemplary immunohistochemical stains of HCC tissues with low or high PAI-1 expression are shown (TMA analysis). d Association between PAI-1 expression and YAP-induced gene signatures (CIN4/CIN25) as well as YAP target genes CTGF and CYR61 in human HCC tissues is shown. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001. Statistical test: Spearman correlation (rs)