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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Yes-associated protein (YAP) induces a secretome phenotype and transcriptionally regulates plasminogen activator Inhibitor-1 (PAI-1) expression in hepatocarcinogenesis

Fig. 1

Identification of the YAP-dependent secretome in hepatocytes. a Exemplary proteome profiling of blood plasma isolated from WT and YAPS127A-transgenic mice revealed significantly different expression of 24 cytokines (17 up and 7 downregulated), (n = 3–5/group). Table summarizes 10 significantly elevated factors that show at least 2-fold induction in plasma samples from YAPS127A-transgenic mice. b Heatmap illustrating expression of significantly regulated genes annotated in the KEGG pathway ‘cytokine-cytokine receptor signaling’ (KEGG: mmu04060) in primary hepatocytes isolated from WT and YAPS127A-transgenic mice 12 weeks after doxycycline withdrawal (n = 3/group). Genes selected for further validation are indicated. c Confirmatory real-time PCR of genes selected from (b) was performed on independent samples derived from primary WT and YAPS127A-positive hepatocytes, (n = 5–7/group). d Real-time PCR analysis of selected candidates on samples isolated from whole tissue lysates of WT and YAPS127A-transgenic mice, (n = 10–16/group)

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