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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Inhibition of αvβ3 integrin impairs adhesion and uptake of tumor-derived small extracellular vesicles

Fig. 6

Proposed model for inhibition of SEV adhesion and cellular uptake by recipient cells upon blockage of αvβ3 integrin. Left panel: in the absence of DisBa-01, tumor cells secrete SEVs that bind to ECM and are taken by non-malignant cells. Right panel: blockage of αvβ3 integrin by DisBa-01 decreases SEV secretion, adhesion to ECM proteins and uptake by recipient cells

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Cell Communication and Signaling

ISSN: 1478-811X