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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Inhibition of αvβ3 integrin impairs adhesion and uptake of tumor-derived small extracellular vesicles

Fig. 5

DisBa-01 decreases GFP-CD63 content. (a) Stacks from confocal images showing reduction of GFP-CD63 intensity 1 h and 4 h after DisBa-01 treatment. CTRL, control. (b) Orthogonal view of DisBa-01-Alexa Fluor-546 internalized on MDA-MB-231-GFP-CD63 cells, evidencing an increased level of red signal in 4 h condition. (c) Quantitation of green fluorescent signal of GFP-CD63. Reduced expression level of CD63 (d) and Alix (e) after treatment with DisBa-01 in western blotting analysis. **p < 0.01; ***p < 0.001; ****p < 0.0001. Scale bar, 10 μm

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Cell Communication and Signaling

ISSN: 1478-811X