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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Inhibition of αvβ3 integrin impairs adhesion and uptake of tumor-derived small extracellular vesicles

Fig. 3

Inhibition of SEV uptake by αvβ3 integrin blocking. a Representative images of SEV uptake in MCF 10A cells labeled with cell tracker red. Arrows indicate internalized SEVs. Ctrl, control. Scale bar, 50 μm. b Integrated intensity of CFSE-labeled SEV internalized in MCF 10A cells; ****p < 0.0001. c Schematic view of transwell system. d Orthogonal view of MCF 10A co-cultured with MDA-MB-GFP-CD63 cells showing cells-derived GFP-CD63 uptake in control (Ctrl) and DisBa-01 (100 and 1000 nM) treated cells. Arrows indicate internalized GFP-CD63. Scale bar, 10 μm. e Quantitation of relative uptake of vesicles; ****p < 0.0001

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Cell Communication and Signaling

ISSN: 1478-811X