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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: The critical role of dysregulated Hh-FOXM1-TPX2 signaling in human hepatocellular carcinoma cell proliferation

Fig. 7

High TPX2 levels correlates with high FOXM1 levels in HCC tumors and with poor survival in patients with HCC. a. Representative photomicrographs of H&E-stained liver tissues and IHC staining of FOXM1 and TPX2 in a human HCC sample and the matched adjacent normal tissue sample in the same section. The areas of carcinoma and adjacent normal tissues were sketched. The subcellular locations of FOXM1 and TPX2 are indicated by red arrows. b-c. FOXM1(b) and TPX2(c) expression levels were graded using the immunohistochemical scores. Data were analyzed using the Wilcoxon matched-pairs signed-rank test. d. Correlation between FOXM1 and TPX2 expression in 66 HCC immunohistochemical samples was plotted as a scatter diagram. Data were analyzed using the Spearman correlation test. e. Protein level of TPX2 and FOXM1 in 6 randomly selected HCC samples were checked via immunoblotting. f-g. Kaplan-Meier overall survival rate analysis of 66 HCC patients grouped by IHC-assessed FOXM1 (e) and TPX2 (f) levels. h-i. Kaplan-Meier disease-free survival rate analysis of 66 HCC patients grouped by IHC-assessed FOXM1 (g) and TPX2 (h) levels

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