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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Orchestration of signaling by structural disorder in class 1 cytokine receptors

Fig. 4

Network rewiring by disorder. Top; Comparison of a long and short isoform of PRLR. a Structural propensities of the PRLR-LF-ICD compared to PRLR-SF1b-ICD illustrated by differences in NMR secondary chemical shifts (SCSs) of Cα. Red coloring indicates lower Cα SCSs in PRLR-SF1b-ICD compared to PRLR-LF-ICD, and hence less helicity. b NMR chemical shift perturbations upon addition of POPC/POPS SUVs to PRLR-SF1b-ICD and c intensity ratios of PRLR-SF1b-ICD in the absence and the presence of POPC/POPS SUVs. Red circles highlight prolines and/or unassigned residues and shaded areas loss of NMR signal upon addition. Bottom; Predicted and selected binding SLiMs in the isoforms of d PRLR, e IL-31Rα (GLMR), and f LEPR (OBR). Introduction of potential new binding SLiMs in the unique sequences are indicated by the sequence of the SLiM, and the presence of SLiMs in the LF of the isoforms is indicated with a “+”. When a SLiM is not present, this is indicated by a “-”. The length of the ICD is indicated by the scale bars on top, and red lines illustrate the length of the unique sequence. “*” indicates a different SLiM compared to the binding site identified by mutations in [148]. Alternative names for the isoforms are given in the second row. For other C1CR isoforms, see Table S2

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