Role of tyrosine kinases in bladder cancer progression: an overview

Zangouei, Amir Sadra; Barjasteh, Amir Hossein; Rahimi, Hamid Reza; Mojarrad, Majid; Moghbeli, Meysam

doi:10.1186/s12964-020-00625-7

Cell Communication and Signaling

Table 1 All of the tyrosine kinases which have been significantly associated with clinicopathological features of BCa patients in the world

From: Role of tyrosine kinases in bladder cancer progression: an overview

Study	Year	Gene	Country	Sample	Results
RTK class I
COOMBS [32]	1993	HER2	UK	91 tumor tissues 99 control tissues	Correlation between tumor grade and HER2 up regulation
SIMON [33]	2003	HER2	Switzerland	2317 tumor tissues	Correlation between tumor grade and HER2 up regulation
NADOUSHAN [34]	2009	HER2	Iran	75 patients	Correlation between tumor grade and HER2 up regulation
Krüger [35]	2002	HER2	Germany	138 patients	Correlation between tumor grade and HER2 up regulation
COOGAN [36]	2004	HER2	USA	54 patients	Correlation between tumor grade and HER2 up regulation
LATIF [37]	2004	HER2	UK	75 patients	Increased HER2 copy number
LATIF [38]	2003	HER2	UK	25 patients	Increased HER2 copy number
FLEISCHMANN [39]	2011	HER2	Switzerland	150 patients	HER2 amplification was correlated with poor prognosis.
HANSEL [40]	2008	HER2	USA	53 patients	HER2 amplification was correlated with high-stage (pT4).
EISSA [41]	2005	HER2	Egypt	88 patients	HER2 expression was correlated with lymph node involvement.
ABDELRAHMAN [42]	2019	HER2	Egypt	60 patients	HER2 up regulation was correlated RFS and PFS.
DING [43]	2015	HER2	China	238 patients	HER2 up regulation was correlated with advanced grade and stage.
BREYER [44]	2016	HER2	Germany	355 patients	HER2 up regulation was correlated with advanced grade and stage.
ARIKAN [45]	2015	HER2	Turkey	44 patients 40 controls	HER2 urinary level was correlated with advanced grade.
KOLLA [46]	2008	HER2	India	90 patients	HER2 expression was correlated with advanced grade, stage, and lymph node metastasis.
KOGA [47]	2011	HER2	Japan	35 patients	HER2 up regulation was correlated with poor prognosis.
INOUE [48]	2014	HER2	Japan	201 patients	HER2 up regulation was correlated with CRT resistance.
SASAKI [49]	2014	HER2	Japan	171 patients	HER2 up regulation was correlated with grade and recurrence.
KIM [50]	2016	HER2	South Korea	6 patients	HER2 protein up regulation and gene amplification
MEMON [51]	2004	HER3, HER4	Denmark	88 patients	HER3 and HER4 up regulations were correlated with good prognosis.
GUNES [52]	2013	EGFR, HER2, ErbB3, ErbB4	Turkey	40 patients	EGFR and HER2 were down regulated and up regulated respectively.
Türkeri [53]	1998	EGFR	Turkey	21 patients	EGFR expression was correlated with stage.
POPOV [54]	2004	EGFR	France	113 patients 10 controls	EGFR expression was correlated with survival.
ARFAOUI [55]	2016	EGFR	Tunisia	64 patients 6 controls	EGFR expression was correlated with grade and stage.
BERGER [56]	1987	EGFR	UK	31 patients	EGFR expression was correlated with grade and stage.
KHALED [57]	2009	EGFR	Egypt	59 patients	EGFR expression was correlated with stage and survival.
LIPPONEN [58]	1994	EGFR, HER2	Finland	234 patients	EGFR expression was correlated with grade and aneuploidy.
MEMON [59]	2006	EGFR, HER2, HER3, HER4	Denmark	88 patients	HER1–4 were correlated with poor prognosis.
KIM [60]	2014	EGFR	Korea	80 patients	EGFR up regulation was correlated with chemo resistance.
COLQUHOUN [61]	2006	EGFR	UK	110 patients	EGFR expression was correlated with recurrence.
Thøgersen [62]	1999	EGFR	Denmark	54 patients	EGFR up regulation was correlated with stage.
MANSOUR [63]	2018	EGFR	Egypt	58 patients	EGFR up regulation was correlated with poor prognosis.
Bryan [64]	2015	EGFR	UK	436 patients 60 controls	EGFR urine levels were correlated with grade and survival.
CHU [65]	2013	EGFR	China	908 patients 1239 controls	Polymorphism was correlated with BCa progression.
MASON [66]	2009	EGFR	USA	857 patients 1191 controls	Polymorphism was correlated with BCa progression.
LI [67]	2015	HER2, EGFR, VEGFR	USA	16 patients	EGFR up regulation
RAJJAYABUN [63, 68]	2005	EGFR, HER2	UK	58 patients	HER2 and EGFR up regulations
IMAI [69]	1995	EGFR, HER2	Japan	30 patients	HER2 and EGFR up regulations were correlated with recurrence.
LI [70]	2018	EGFR, HER2	China	56 patients 10 controls	HER2 and EGFR expressions were correlated with stage.
KASSOUF [71]	2008	EGFR, HER2, ErbB-3, ErbB-4	Canada	248 tumors	EGFR and ErbB-4 expressions were correlated with grade and survival.
RTK class II
GONZALEZ-ROBIN [72]	2014	IGF1R	USA	100 patients	IGF1R expression was correlated with pT classification.
ROCHESTER [73]	2007	IGF1R	UK	40 tumor tissues 15 control tissues	IGF1R expression was correlated with pT classification.
Metalli [74]	2010	IGF1R	USA	5 patients	IGF1R up regulation
Iozzo [75]	2011	IGF1R	USA	40 patients	IGF1R up regulation
RTK class V
MARZIONI [76]	2009	FGFRI, FGFR2	Italy	17 patients	FGFRI, FGFR2, and bFGF up regulations
Dueñas [77]	2015	PIK3CA, FGFR3	Spain	87 patients	PIK3CA and FGFR3 mutations were correlated with grade and recurrence.
JUANPERE [78]	2012	FGFR3, PIK3CA, KRAS, AKT1,	Spain	88 patients	Mutations were correlated with grade.
KOMPIER [79]	2010	FGFR3, HRAS, KRAS, NRAS, PIK3CA	Netherlands	257 patients	Mutations were correlated with grade.
PANDITH [80]	2016	FGFR3	India	65 patients	Mutation was correlated with grade and stage.
BERTZ [81]	2014	FGFR3	Germany	61 patients	Mutation was correlated with prognosis and recurrence.
BILLEREY [82]	2013	FGFR3	France	132 patients	FGFR3 mutation was correlated with pT classification.
VAN OERS [83]	2007	FGFR3	Germany	255 patients	FGFR3 mutation was correlated with grade.
VAN OERS [84]	2009	FGFR3	UK, France	280 patients	FGFR3 mutation was correlated with pT classification and prognosis.
MHAWECH-FAUCEGLIA [85]	2006	FGFR3	USA	254 patients	FGFR3 up regulation was correlated with grade and stage.
BREYER [86]	2018	FGFR3	Germany	296 patients	FGFR3 expression was correlated with grade.
BODOOR [87]	2010	FGFR3	Jordan	130 patients	FGFR3 expression was correlated with grade and stage.
PEDREGOSA [88]	2017	FGFR3	Spain	55 patients	FGFR3 expression was correlated with tumor size and survival.
YANG [89]	2018	FGFR3	China	52 patients	FGFR3 mutation was associated with better prognosis.
ABDUL-MAKSOUD [90]	2016	FGFR1	Egypt	80 patients 80 controls	FGFR1 expression was correlated with grade and stage.
RTK classes of VIII, IX, and XIII
MCNEIL [91]	2014	c-MET	USA	183 patients	Urinary MET levels were correlated with muscle invasion.
KIM [92]	2015	c-MET, AXL, PDGFR	Korea	165 patients 34 controls	Expressions were correlated with prognosis.
CHENG [93]	2005	c-MET	Taiwan	183 patients	RON and MET expressions were correlated with survival.
Abraham [94]	2006	EphA2	USA	64 tumor tissues 13 normal tissues	EphA2 expression was correlated with tumor stage.
XIA [95]	2006	EphB4	USA	15 patients	EphB4 up regulation
Xie [96]	2017	DDR1	China	44 patients	DDR1 expression was correlated with poor prognosis.
Tsai [97]	2016	DDR2	Taiwan	340 patients	DDR2 up regulation was correlated with poor prognosis, infiltrative pattern, higher grade, advanced T stage, and metastatic status.
Other tyrosine kinase receptors
LAI [98]	2010	BDNF, TrkB	Taiwan	116 tumor tissues	BDNF and TrkB up regulations
PAN [99]	2005	c-KIT	USA	52 patients	c-KIT up regulation
SHAMS [100]	2013	c-KIT	Egypt	120 patients	c-KIT up regulation
Non-receptor tyrosine kinases
ASAI [101]	2018	FES	Japan	203 patients	FES up regulation was correlated with poor prognosis.
NOMURA [102]	2015	DYRK2	Japan	44 patients	DYRK2 expression was correlated with survival.
GUO [103]	2011	ETK	USA	233 patients	ETK up regulation was correlated with grade and prognosis.

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ISSN: 1478-811X

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