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Table 3 Systemic characteristics and single-kidney function in pigs with renovascular disease (RVD) 4 weeks after treatment with MSC-derived extracellular vesicles (EVs)

From: Metabolic syndrome increases senescence-associated micro-RNAs in extracellular vesicles derived from swine and human mesenchymal stem/stromal cells

Parameter

Lean

RVD

RVD+ Lean-EVs

RVD + MetS-EVs

SBP (mmHg)

127.0 ± 15.3

159.8 ± 22.3*

142.3 ± 12.3*

170.8 ± 12.6*

DBP (mmHg)

92.8 ± 11.0

115.0 ± 17.7*

108.0 ± 10.5*

105.7 ± 4.5*

MAP (mmHg)

90.7 ± 4.4

131.9 ± 17.3*

116.8 ± 12.5*

127.4 ± 6.3*

Degree of stenosis (%)

0

64.2 ± 19.6*

65.0 ± 8.4*

65.8 ± 6.6*

Serum creatinine (mg/dL)

1.44 ± 0.21

1.77 ± 0.23*

1.48 ± 0.29†

1.76 ± 0.26*‡

  1. SBP systolic blood pressure, DBP diastolic blood pressure, MAP mean arterial pressure
  2. n = 6 each group. *p < 0.05 vs. Lean; †p < 0.05 vs. RVD; ‡p < 0.05 vs. RVD + Lean-EVs