TY - JOUR AU - Villanueva, A. PY - 2019 DA - 2019// TI - Hepatocellular carcinoma JO - N Engl J Med VL - 380 UR - https://doi.org/10.1056/NEJMra1713263 DO - 10.1056/NEJMra1713263 ID - Villanueva2019 ER - TY - JOUR AU - Bray, F. AU - Ferlay, J. AU - Soerjomataram, I. AU - Siegel, R. L. AU - Torre, L. A. AU - Jemal, A. PY - 2018 DA - 2018// TI - Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries JO - CA Cancer J Clin VL - 68 UR - https://doi.org/10.3322/caac.21492 DO - 10.3322/caac.21492 ID - Bray2018 ER - TY - JOUR AU - Kulik, L. AU - El-Serag, H. B. PY - 2019 DA - 2019// TI - Epidemiology and Management of Hepatocellular Carcinoma JO - Gastroenterology. VL - 156 UR - https://doi.org/10.1053/j.gastro.2018.08.065 DO - 10.1053/j.gastro.2018.08.065 ID - Kulik2019 ER - TY - JOUR AU - Yang, L. AU - Venneti, S. AU - Nagrath, D. PY - 2017 DA - 2017// TI - Glutaminolysis: a Hallmark of cancer metabolism JO - Annu Rev Biomed Eng VL - 19 UR - https://doi.org/10.1146/annurev-bioeng-071516-044546 DO - 10.1146/annurev-bioeng-071516-044546 ID - Yang2017 ER - TY - JOUR AU - Nakagawa, H. AU - Hayata, Y. AU - Kawamura, S. AU - Yamada, T. AU - Fujiwara, N. AU - Koike, K. PY - 2018 DA - 2018// TI - Lipid metabolic reprogramming in hepatocellular carcinoma JO - Cancers (Basel) VL - 10 UR - https://doi.org/10.3390/cancers10110447 DO - 10.3390/cancers10110447 ID - Nakagawa2018 ER - TY - JOUR AU - Ying, H. AU - Kimmelman, A. C. AU - Lyssiotis, C. A. AU - Hua, S. AU - Chu, G. C. AU - Fletcher-Sananikone, E. PY - 2012 DA - 2012// TI - Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism JO - Cell. VL - 149 UR - https://doi.org/10.1016/j.cell.2012.01.058 DO - 10.1016/j.cell.2012.01.058 ID - Ying2012 ER - TY - JOUR AU - Li, Q. AU - Zhao, Q. AU - Zhang, J. AU - Zhou, L. AU - Zhang, W. AU - Chua, B. PY - 2019 DA - 2019// TI - The protein phosphatase 1 complex is a direct target of AKT that links insulin signaling to hepatic glycogen deposition JO - Cell Rep VL - 28 UR - https://doi.org/10.1016/j.celrep.2019.08.066 DO - 10.1016/j.celrep.2019.08.066 ID - Li2019 ER - TY - JOUR AU - Levine, A. J. AU - Puzio-Kuter, A. M. PY - 2010 DA - 2010// TI - The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes JO - Science. VL - 330 UR - https://doi.org/10.1126/science.1193494 DO - 10.1126/science.1193494 ID - Levine2010 ER - TY - JOUR AU - Liu, J. AU - Zhang, C. AU - Hu, W. AU - Feng, Z. PY - 2015 DA - 2015// TI - Tumor suppressor p53 and its mutants in cancer metabolism JO - Cancer Lett VL - 356 UR - https://doi.org/10.1016/j.canlet.2013.12.025 DO - 10.1016/j.canlet.2013.12.025 ID - Liu2015 ER - TY - JOUR AU - Hoxhaj, G. AU - Manning, B. D. PY - 2020 DA - 2020// TI - The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism JO - Nat Rev Cancer VL - 20 UR - https://doi.org/10.1038/s41568-019-0216-7 DO - 10.1038/s41568-019-0216-7 ID - Hoxhaj2020 ER - TY - JOUR AU - Peyrou, M. AU - Bourgoin, L. AU - Poher, A. L. AU - Altirriba, J. AU - Maeder, C. AU - Caillon, A. PY - 2015 DA - 2015// TI - Hepatic PTEN deficiency improves muscle insulin sensitivity and decreases adiposity in mice JO - J Hepatol VL - 62 UR - https://doi.org/10.1016/j.jhep.2014.09.012 DO - 10.1016/j.jhep.2014.09.012 ID - Peyrou2015 ER - TY - JOUR AU - Yehia, L. AU - Keel, E. AU - Eng, C. PY - 2020 DA - 2020// TI - The clinical Spectrum of PTEN mutations JO - Annu Rev Med VL - 71 UR - https://doi.org/10.1146/annurev-med-052218-125823 DO - 10.1146/annurev-med-052218-125823 ID - Yehia2020 ER - TY - JOUR AU - Cordero-Espinoza, L. AU - Hagen, T. PY - 2013 DA - 2013// TI - Increased concentrations of fructose 2,6-bisphosphate contribute to the Warburg effect in phosphatase and tensin homolog (PTEN)-deficient cells JO - J Biol Chem VL - 288 UR - https://doi.org/10.1074/jbc.M113.510289 DO - 10.1074/jbc.M113.510289 ID - Cordero-Espinoza2013 ER - TY - JOUR AU - Chen, F. AU - Zhuang, M. AU - Zhong, C. AU - Peng, J. AU - Wang, X. AU - Li, J. PY - 2015 DA - 2015// TI - Baicalein reverses hypoxia-induced 5-FU resistance in gastric cancer AGS cells through suppression of glycolysis and the PTEN/Akt/HIF-1alpha signaling pathway JO - Oncol Rep VL - 33 UR - https://doi.org/10.3892/or.2014.3550 DO - 10.3892/or.2014.3550 ID - Chen2015 ER - TY - JOUR AU - Ferrick, D. A. AU - Neilson, A. AU - Beeson, C. PY - 2008 DA - 2008// TI - Advances in measuring cellular bioenergetics using extracellular flux JO - Drug Discov Today VL - 13 UR - https://doi.org/10.1016/j.drudis.2007.12.008 DO - 10.1016/j.drudis.2007.12.008 ID - Ferrick2008 ER - TY - JOUR AU - Harris, P. S. AU - Hansen, R. M. AU - Gray, M. E. AU - Massoud, O. I. AU - McGuire, B. M. AU - Shoreibah, M. G. PY - 2019 DA - 2019// TI - Hepatocellular carcinoma surveillance: an evidence-based approach JO - World J Gastroenterol VL - 25 UR - https://doi.org/10.3748/wjg.v25.i13.1550 DO - 10.3748/wjg.v25.i13.1550 ID - Harris2019 ER - TY - JOUR AU - Chen, D. AU - Li, Z. AU - Cheng, Q. AU - Wang, Y. AU - Qian, L. AU - Gao, J. PY - 2019 DA - 2019// TI - Genetic alterations and expression of PTEN and its relationship with cancer stem cell markers to investigate pathogenesis and to evaluate prognosis in hepatocellular carcinoma JO - J Clin Pathol VL - 72 UR - https://doi.org/10.1136/jclinpath-2019-205769 DO - 10.1136/jclinpath-2019-205769 ID - Chen2019 ER - TY - JOUR AU - Khalid, A. AU - Hussain, T. AU - Manzoor, S. AU - Saalim, M. AU - Khaliq, S. PY - 2017 DA - 2017// TI - PTEN: a potential prognostic marker in virus-induced hepatocellular carcinoma JO - Tumour Biol VL - 39 UR - https://doi.org/10.1177/1010428317705754 DO - 10.1177/1010428317705754 ID - Khalid2017 ER - TY - JOUR AU - Fu, X. AU - Wen, H. AU - Jing, L. AU - Yang, Y. AU - Wang, W. AU - Liang, X. PY - 2017 DA - 2017// TI - MicroRNA-155-5p promotes hepatocellular carcinoma progression by suppressing PTEN through the PI3K/Akt pathway JO - Cancer Sci VL - 108 UR - https://doi.org/10.1111/cas.13177 DO - 10.1111/cas.13177 ID - Fu2017 ER - TY - JOUR AU - Li, Y. AU - Ye, Y. AU - Feng, B. AU - Qi, Y. PY - 2017 DA - 2017// TI - Long noncoding RNA lncARSR promotes doxorubicin resistance in hepatocellular carcinoma via modulating PTEN-PI3K/Akt pathway JO - J Cell Biochem VL - 118 UR - https://doi.org/10.1002/jcb.26107 DO - 10.1002/jcb.26107 ID - Li2017 ER - TY - JOUR AU - Han, Y. AU - Chen, M. AU - Wang, A. AU - Fan, X. PY - 2019 DA - 2019// TI - STAT3-induced upregulation of lncRNA CASC11 promotes the cell migration, invasion and epithelial-mesenchymal transition in hepatocellular carcinoma by epigenetically silencing PTEN and activating PI3K/AKT signaling pathway JO - Biochem Biophys Res Commun VL - 508 UR - https://doi.org/10.1016/j.bbrc.2018.11.092 DO - 10.1016/j.bbrc.2018.11.092 ID - Han2019 ER - TY - JOUR AU - Lin, H. AU - Huang, Z. P. AU - Liu, J. AU - Qiu, Y. AU - Tao, Y. P. AU - Wang, M. C. PY - 2018 DA - 2018// TI - MiR-494-3p promotes PI3K/AKT pathway hyperactivation and human hepatocellular carcinoma progression by targeting PTEN JO - Sci Rep VL - 8 UR - https://doi.org/10.1038/s41598-018-28519-2 DO - 10.1038/s41598-018-28519-2 ID - Lin2018 ER - TY - JOUR AU - Kim, J. AU - Jung, K. H. AU - Choi, J. G. PY - 2020 DA - 2020// TI - Artemisiae Iwayomogii Herba inhibits growth, motility, and the PI3K/AKT/mTOR signaling pathway in hepatocellular carcinoma cells JO - Planta Med VL - 86 UR - https://doi.org/10.1055/a-1167-4284 DO - 10.1055/a-1167-4284 ID - Kim2020 ER - TY - JOUR AU - Lee, M. AU - Ko, H. AU - Yun, M. PY - 2018 DA - 2018// TI - Cancer metabolism as a mechanism of treatment resistance and potential therapeutic target in hepatocellular carcinoma JO - Yonsei Med J VL - 59 UR - https://doi.org/10.3349/ymj.2018.59.10.1143 DO - 10.3349/ymj.2018.59.10.1143 ID - Lee2018 ER - TY - JOUR AU - Lee, M. AU - Yoon, J. H. PY - 2015 DA - 2015// TI - Metabolic interplay between glycolysis and mitochondrial oxidation: the reverse Warburg effect and its therapeutic implication JO - World J Biol Chem VL - 6 UR - https://doi.org/10.4331/wjbc.v6.i3.148 DO - 10.4331/wjbc.v6.i3.148 ID - Lee2015 ER - TY - JOUR AU - Shang, R. Z. AU - Qu, S. B. AU - Wang, D. S. PY - 2016 DA - 2016// TI - Reprogramming of glucose metabolism in hepatocellular carcinoma: Progress and prospects JO - World J Gastroenterol VL - 22 UR - https://doi.org/10.3748/wjg.v22.i45.9933 DO - 10.3748/wjg.v22.i45.9933 ID - Shang2016 ER - TY - JOUR AU - Beyoglu, D. AU - Idle, J. R. PY - 2013 DA - 2013// TI - The metabolomic window into hepatobiliary disease JO - J Hepatol VL - 59 UR - https://doi.org/10.1016/j.jhep.2013.05.030 DO - 10.1016/j.jhep.2013.05.030 ID - Beyoglu2013 ER - TY - JOUR AU - Wang, Y. AU - Lin, B. AU - Li, H. AU - Lan, L. AU - Yu, H. AU - Wu, S. PY - 2017 DA - 2017// TI - Galangin suppresses hepatocellular carcinoma cell proliferation by reversing the Warburg effect JO - Biomed Pharmacother VL - 95 UR - https://doi.org/10.1016/j.biopha.2017.09.056 DO - 10.1016/j.biopha.2017.09.056 ID - Wang2017 ER - TY - JOUR AU - Liberti, M. V. AU - Locasale, J. W. PY - 2016 DA - 2016// TI - The Warburg effect: how does it benefit cancer cells? JO - Trends Biochem Sci VL - 41 UR - https://doi.org/10.1016/j.tibs.2015.12.001 DO - 10.1016/j.tibs.2015.12.001 ID - Liberti2016 ER - TY - JOUR AU - Spencer, N. Y. AU - Stanton, R. C. PY - 2019 DA - 2019// TI - The Warburg effect, lactate, and nearly a century of trying to cure cancer JO - Semin Nephrol VL - 39 UR - https://doi.org/10.1016/j.semnephrol.2019.04.007 DO - 10.1016/j.semnephrol.2019.04.007 ID - Spencer2019 ER - TY - JOUR AU - Garcia-Cao, I. AU - Song, M. S. AU - Hobbs, R. M. AU - Laurent, G. AU - Giorgi, C. AU - Boer, V. C. PY - 2012 DA - 2012// TI - Systemic elevation of PTEN induces a tumor-suppressive metabolic state JO - Cell. VL - 149 UR - https://doi.org/10.1016/j.cell.2012.02.030 DO - 10.1016/j.cell.2012.02.030 ID - Garcia-Cao2012 ER - TY - JOUR AU - Li, Y. AU - He, L. AU - Zeng, N. AU - Sahu, D. AU - Cadenas, E. AU - Shearn, C. PY - 2013 DA - 2013// TI - Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling regulates mitochondrial biogenesis and respiration via estrogen-related receptor alpha (ERRalpha) JO - J Biol Chem VL - 288 UR - https://doi.org/10.1074/jbc.M113.450353 DO - 10.1074/jbc.M113.450353 ID - Li2013 ER - TY - JOUR AU - Bao, L. AU - Li, X. AU - Lin, Z. PY - 2019 DA - 2019// TI - PTEN overexpression promotes glioblastoma death through triggering mitochondrial division and inactivating the Akt pathway JO - J Recept Signal Transduct Res VL - 39 UR - https://doi.org/10.1080/10799893.2019.1655051 DO - 10.1080/10799893.2019.1655051 ID - Bao2019 ER - TY - JOUR AU - Zhang, J. AU - Li, L. AU - Peng, Y. AU - Chen, Y. AU - Lv, X. AU - Li, S. PY - 1865 DA - 1865// TI - Surface chemistry induces mitochondria-mediated apoptosis of breast cancer cells via PTEN/PI3K/AKT signaling pathway JO - Biochim Biophys Acta, Mol Cell Res VL - 2018 ID - Zhang1865 ER -