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Table 1 Secretion or degradation of cargo through an amphisome-dependent mechanism

From: Focus on the morphogenesis, fate and the role in tumor progression of multivesicular bodies

Authors/Years Cargoes Cell lines Amphisome’s judgment Ref
Secretion of cargo through an Amphisome-Dependent Mechanism
Dennis K. Jeppesen et al./2019 dsDNA and histones DKO-1, Gli36 SIM, Colocalization (CD63、LC3) [13]
Kaizhe Wang et al./2019 Autophagy-associated proteins Hela, MDA-MB-231 TEM, Colocalization (CD63、LC3) [38]
Sandra Atienzar-Aroca et al./2018 VEGFR2 ARPE-19 TEM [125]
Georgia Minakaki et al./2018 SNCA/alpha-synuclein Human neuroglioma cells TEM [120]
Elisabet Barbero-Camps et al./2018 Amyloid beta (Ab) Neuron-rich primary cultures [37]
Ying-Da Chen et al./2017 Annexin A2 Human lung epithelial cells. Colocalization (CD63、LC3) [126]
Nina Pettersen Hessvik et al./2016 Autophagy-associated protein (NBR1, p62, LC3, WIPI2 etc) PC-3 TEM [64]
Degration of cargo through an Amphisome-Dependent Mechanism
Amengual J et al./2018 Apolipoprotein B100 Huh7 Colocalization (EEA1、LC3) [127]
Jakob Mejlvang et al./2018 Autophagy receptors p62/SQSTM1, NBR1, NDP52, NCOA4 A549, BJ Immuno-EM (p62), Colocalization (Rab5、LC3) [63]
Guodong Wang et al./2017 Endocytic PEI-Alg NPs Endothelial progenitor cells TEM [128]
Prasad Tammineni et al./2017 Association of soluble Aβ oligomers COS7, Colocalization (Rab7、LC3) [129]
Ruud H. Wijdeven et al./2016 Cytosolic components Hela, HEK 293 T Colocalization
(LC3、CD63)
[123]
Zhihua Chen et al./2016 Endocytic Ultrafine PM Human bronchial epithelial cells TEM [121]
Sovan Sarka et al./2013 Cholesterol MEF Colocalization (Rab7、LC3) [34]
Yusong Zhang, et al./2012 Endocytic HMGB1 HepG2 Colocalization (HMGB1、LC3) [122]
  1. SIM Structured illumination microscopy, TEM Transmission electron microscopy, Immuno-EM Immuno-electron microscop, Colocalization Immunofluorescence colocalization, VEGFR2 Vascular endothelial growth factor receptor, HMGB1 High mobility group box 1
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