Fig. 3
From: Focus on the morphogenesis, fate and the role in tumor progression of multivesicular bodies
EVs secretion in eukaryotes. a. Multiple types of EVs originate through multivesicular endosome, plasma membrane and intracellular plasma membrane-connected compartment (IPMC) budding pathways, respectively. Importantly, exosomes are the contributors of MVBs to the total EV population(s), which are secreted during the fusion of multivesicular late endocytic compartment MVBs with the plasma membrane. Meanwhile, invadopodia (plasma membrane extensions) serve as key docking sites for exosome-containing MVBs and effectively control the quantity of exosomes secreted from cancer cells. b and c. Electron microscopy images of classical MVBs and MVB-like EV clusters, respectively. Images (b and c) were kindly provided by Fuhui Zhang (Department of Cell Biology, Key Laboratory of Medical Cell Biology, Ministry of Education of the PRC, China Medical University, China)