Fig. 1
From: Focus on the morphogenesis, fate and the role in tumor progression of multivesicular bodies
(Multivesicular body) MVB morphogenesis and possible sorting pathways: exosome release, back-fusion, and degradation in the lysosome and amphisome-dependent degradation or secretion. (1) the MVB may fuse with the plasma membrane and release the ILVs as exosomes. (2) Membrane cargo (ligand/receptor) may be recycled back to the plasma membrane or may be targeted to ILVs in the MVB. (3) MVBs can target internalized membrane cargoes (ligand/receptors) for degradation in the lysosome by fusing with lysosomes. (4) The amphisome fuses with lysosomes to form the autolysosome for degradation of cargo, or fuses with the plasma membrane, triggering extracellular component release, including dsDNA, proteins and lipids and separately, ILVs act as exosomes