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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: PIM1 accelerates prostate cancer cell motility by phosphorylating actin capping proteins

Fig. 4

CP dephosphorylation increases actin protrusion numbers at cell edges. a-c PC-3 cells plated on coverslips were transiently transfected to overexpress wild-type (WT) Capza1 and Capzb2 or their phosphodeficient (SA) or phosphomimicking (SE) mutants. Actin filaments were stained by phalloidin, and actin protrusion numbers and lengths were measured. Shown are averages from at least three individual samples along with representative images for the Capzb2 phosphomutants. The increase in actin protrusion numbers in SA samples is pointed out by arrows. Scale bars represent 10 μm

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