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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: PIM1 accelerates prostate cancer cell motility by phosphorylating actin capping proteins

Fig. 3

CP phosphorylation promotes PC-3 cell migration. a-b Wound healing assays were performed with PC-3 cells transiently overexpressing Capza1/b2 wild-type (WT) proteins and/or phosphodeficient (SA) or phosphomimicking (SE), single, double (2X) or triple (3X) mutants. c Similar assays were performed with cells that overexpressed only Capzb2 variants and were treated with DMSO (0.1%) or 10 μM PIM inhibitor DHPCC-9. Shown are averages from at least three independent experiments with three parallel samples along with representative images. Wound edges are lined in white. Scale bars represent 20 μm. Expression plasmid names are shown on top of the graph bars

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