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Table 5 .

From: A comparative study on normal and obese mice indicates that the secretome of mesenchymal stromal cells is influenced by tissue environment and physiopathological conditions

vWAT HFD REACTOME PATHS (25)

Anchoring fibril formation

APC/C:Cdc20 mediated degradation of Securin

APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1

Assembly of collagen fibrils and other multimeric structures

Autodegradation of Cdh1 by Cdh1:APC/C

CDK-mediated phosphorylation and removal of Cdc6

CDT1 association with the CDC6:ORC:origin complex

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

Collagen chain trimerization

Collagen degradation

Cross-presentation of soluble exogenous antigens (endosomes)

Crosslinking of collagen fibrils

Defective CFTR causes cystic fibrosis

Degradation of AXIN

Hh mutants abrogate ligand secretion

Hh mutants that don’t undergo autocatalytic processing are degraded by ERAD

HSF1 activation

Orc1 removal from chromatin

Platelet degranulation

Post-translational protein phosphorylation

Regulation of activated PAK-2p34 by proteasome mediated degradation

Regulation of ornithine decarboxylase (ODC)

Regulation of RAS by GAPs

SCF-beta-TrCP mediated degradation of Emi1

Vif-mediated degradation of APOBEC3G

sWAT HFD REACT PATHS (15)

Assembly of collagen fibrils and other multimeric structures

Autodegradation of Cdh1 by Cdh1:APC/C

Cross-presentation of soluble exogenous antigens (endosomes)

Crosslinking of collagen fibrils

Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)

Elastic fibre formation

Hh mutants abrogate ligand secretion

Hh mutants that don’t undergo autocatalytic processing are degraded by ERAD

Laminin interactions

Mycobacterium tuberculosis biological processes

Platelet degranulation

Post-translational protein phosphorylation

Regulation of ornithine decarboxylase (ODC)

SCF-beta-TrCP mediated degradation of Emi1

Vif-mediated degradation of APOBEC3G

BM HFD REACT PATHS (20)

Anchoring fibril formation

Assembly of collagen fibrils and other multimeric structures

Collagen biosynthesis and modifying enzymes

Collagen chain trimerization

Collagen degradation

Collagen formation

Cross-presentation of soluble exogenous antigens (endosomes)

Crosslinking of collagen fibrils

Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)

Degradation of the extracellular matrix

ECM proteoglycans

Elastic fibre formation

HSF1 activation

Laminin interactions

Molecules associated with elastic fibres

NCAM1 interactions

Neutrophil degranulation

Platelet degranulation

Post-translational protein phosphorylation

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)