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Table 4 .

From: A comparative study on normal and obese mice indicates that the secretome of mesenchymal stromal cells is influenced by tissue environment and physiopathological conditions

vWAT ND REACTOME PATHS (27)

APC/C:Cdc20 mediated degradation of Securin

APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1

Autodegradation of Cdh1 by Cdh1:APC/C

CDK-mediated phosphorylation and removal of Cdc6

CDT1 association with the CDC6:ORC:origin complex

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

Cross-presentation of soluble exogenous antigens (endosomes)

Defective CFTR causes cystic fibrosis

Degradation of AXIN

Eukaryotic Translation Termination

Formation of a pool of free 40S subunits

Hh mutants abrogate ligand secretion

Hh mutants that don’t undergo autocatalytic processing are degraded by ERAD

HSF1 activation

L13a-mediated translational silencing of Ceruloplasmin expression

Mycobacterium tubercolisis biological processes

Orc1 removal from chromatin

Peptide chain elongation

Platelet degranulation

Post-translational protein phosphorylation

Regulation of activated PAK-2p34 by proteasome mediated degradation

Regulation of ornithine decarboxylase (ODC)

Regulation of RAS by GAPs

Response to elevated platelet cytosolic Ca2+

SCF-beta-TrCP mediated degradation of Emi1

Selenocysteine synthesis

Vif-mediated degradation of APOBEC3G

sWAT ND REACTOME PATHS (13)

Anchoring fibril formation

Assembly of collagen fibrils and other multimeric structures

Cross-presentation of soluble exogenous antigens (endosomes)

Crosslinking of collagen fibrils

Elastic fibre formation

Hh mutants that don’t undergo autocatalytic processing are degraded by ERAD

Laminin interactions

Mycobacterium tuberculosis biological processes

Post-translational protein phosphorylation

Prefoldin mediated transfer of substrate to CCT/TriC

Regulation of ornithine decarboxylase (ODC)

SCF-beta-TrCP mediated degradation of Emi1

Vif-mediated degradation of APOBEC3G

BM ND REACT PATHS (17)

Assembly of collagen fibrils and other multimeric structures

Collagen chain trimerization

Collagen degradation

Cross-presentation of soluble exogenous antigens (endosomes)

Crosslinking of collagen fibrils

Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)

Defective CHST6 causes MCDC1

Defective ST3GAL3 causes MCT12 and EIEE15

Diseases associated with glycosaminoglycan metabolism

ECM proteoglycans

Elastic fibre formation

Laminin interactions

Molecules associated with elastic fibres

Platelet degranulation

Post-translational protein phosphorylation

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

SCF-beta-TrCP mediated degradation of Emi1