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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: A comparative study on normal and obese mice indicates that the secretome of mesenchymal stromal cells is influenced by tissue environment and physiopathological conditions

Fig. 3

Platelet degranulation pathway. This pathway consists of several networks: ABCC4 accumulation of dense granule contents; exocytosis of platelet dense granule content; surface deployment of platelet dense granule membrane components; exocytosis of platelet alpha granule contents; surface deployment of platelet alpha granule membrane components; release of platelet cytosolic components; release of platelet secretory granule components; and exocytosis of proactivator polypeptide. Platelets are activated following the interaction between ligands, such as ADP and TXA2 (Tromboxane A2), and their cognate receptors on the platelet cell surface. After activation, platelets release the contents of three distinct types of preformed intracellular vesicles. Dense granules (δ granules) contain platelet agonists, and lysosomes contain glycosidases and acid proteases. The α granules release adhesive proteins, prothrombotic factors, and pro-inflammatory factors. Additional file 4 reports the proteins of vWAT-MSC, sWAT-MSC, and BM-MSC secretomes that belong to these networks

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Cell Communication and Signaling

ISSN: 1478-811X