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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: A comparative study on normal and obese mice indicates that the secretome of mesenchymal stromal cells is influenced by tissue environment and physiopathological conditions

Fig. 2

Cross-presentation of soluble exogenous antigens (endosomes) pathway. The pathway consists of three main networks: antigen processing—cross-presentation; antigen presentation—folding, assembly, and peptide loading of class I MHC; and antigen processing—ubiquitination and proteasome degradation. During the presentation process, antigen proteins are degraded into peptides by proteases in the proteasome. Peptides are then delivered to the endoplasmic reticulum (ER) through heat shock proteins and the transporter associated with antigen processing (TAP), which transport peptides from cytosol into the ER lumen. Several ER chaperones (calnexin, tapasin, calreticulin, etc.) contribute to MHC-I assembly. Peptides are loaded into the MHC-I peptide binding groove; this complex exits the ER and is transported to Golgi and then to the cell surface by exocytic vesicles. Naïve T cells (CD8+) are activated by interacting with peptide-MHC-I complexes. Additional file 4 reports the proteins of vWAT-MSC, sWAT-MSC, and BM-MSC secretomes that belong to the above-indicated networks

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Cell Communication and Signaling

ISSN: 1478-811X