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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: RelB sustains endocrine resistant malignancy: an insight of noncanonical NF-κB pathway into breast Cancer progression

Fig. 8

Schematic presentation of the suggested mechanistic integration involved in BCa endocrine-resistant malignancy. In the early stages of BCa, the ER-responsive signal pathway initiates tumorigenesis and promotes local tumor growth. Ultimately, the activation of the noncanonical NF-κB signal pathway predominantly substitutes ER function to sustain BCa metastasis at the estrogen-deprived condition

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