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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: RelB sustains endocrine resistant malignancy: an insight of noncanonical NF-κB pathway into breast Cancer progression

Fig. 3

Determination of RelB-enhanced BCa cell survival and growth. a RelB was ectopically expressed in ER-positive BCa cells by stably transfected a human RelB cDNA construct. b RelB was knocked out in TNBC cells using a CRISPR-Cas9 gene edition system. c, d The relative NF-κB activity was quantified in RelB-manipulated BCa cells. e, f The survival rates in the RelB-manipulated BCa cells were examined by colony formation assay. g-j The proliferation rates in the RelB-manipulated BCa cells were quantified by CCK-8 assay. Mean ± SD was representative of three independent experiments carried out in duplication. *(P < 0.05), **(P < 0.01) show the significances between two groups as indicated

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