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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: AKT/FOXO1 axis links cross-talking of endothelial cell and pericyte in TIE2-mutated venous malformations

Fig. 6

RAPA promotes the interaction of ECs and SMCs. a, b Transwell assay was used to study the migration ability of SMCs after co-culturing with NC, TIE2-WT and TIE2-L914F mutant ECs treated with DMSO or rapamycin over a period of 24 h. c, d Different groups of ECs were treated with DMSO or rapamycin (RAPA), and then co-cultured with SMCs. The expression of OPN and α-SMA were measured in SMCs by western blot. Scale bar, 100 μm. The data are means ± SEM (n = 3). ns: no significant, *P < 0.05, **P < 0.01

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